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Do Language Models Dream of Binding Molecules? Benchmarking LLMs under Spatial Constraints

12 upvotes · 20 JUL 2026 · Thomas MacDougall, Maksim Kuznetsov, Roman Schutski et al.

This paper evaluates whether language models can be used to generate molecules that fit specific 3D constraints, such as protein pockets and spatial relationships between molecules. Practitioners in the field of drug design might care about this research because it could lead to more efficient and effective methods for generating candidate molecules.